Subject(s)
Female , Humans , Adult , Middle Aged , Fasciitis/diagnosis , Forearm , Fasciitis , Diagnosis, DifferentialSubject(s)
Humans , Infant, Newborn , Skin Diseases/pathology , Skin Diseases/congenital , Histiocytosis, Langerhans-Cell/pathology , Histiocytosis, Langerhans-Cell/congenital , Skin Diseases/diagnosis , Skin Diseases/therapy , Histiocytosis, Langerhans-Cell/diagnosis , Histiocytosis, Langerhans-Cell/therapy , Remission, Spontaneous , Diagnosis, Differential , PrognosisABSTRACT
Background: Human T-lymphotropic virus-1 (HTLV-1) infection has been associated with the pathogenesis of cutaneous T cell lymphomas (CTCL). Aim: To search for HTLV-1 DNA in skin biopsies of patients with CTCL. Material and Methods: A retrospective study was conducted using 25 biopsies of patients with CTCL. DNA was extracted from lymphoid tissue by microdissection. A nested PCR was conducted to detect HTLV-1 genome using primers for the tax region. As negative controls, four cases of superficial perivascular dermatitis were chosen. As positive controls, five cases of T-cell leukemia/lymphoma (ATCL) were studied. Results: A positive reaction was found in 3 of 25 cases. These biopsies corresponded to a case of Mycosis Fungoides, a case of CD30 (-) T-cell lymphoma and a case of lymphomatoid papulosis. Search was negative in the four cases of superficial perivascular dermatitis and positive in four cases of adult T-cell leukemia/lymphoma (ATCL). Conclusions: HTLV-1 DNA search in tissues is a useful tool recommended to study T-cell lymphomas. HTLV-1 infection only occurs in sporadic cases but may contribute to tumor aggressiveness and prognosis.
Subject(s)
Adult , Aged , Child, Preschool , Female , Humans , Male , Middle Aged , Young Adult , DNA, Viral/analysis , HTLV-I Infections/virology , Human T-lymphotropic virus 1/genetics , Lymphoma, T-Cell, Cutaneous/virology , Mycosis Fungoides/virology , Skin Neoplasms/virology , Biopsy , Case-Control Studies , HTLV-I Infections/pathology , Immunohistochemistry , Lymphoma, T-Cell, Cutaneous/pathology , Mycosis Fungoides/pathology , Polymerase Chain Reaction , Retrospective Studies , Skin Neoplasms/pathologyABSTRACT
El cáncer de ovario es la segunda neoplasia maligna ginecológica más común, pero la principal causa de muerte entre las mujeres que padecen algún cáncer ginecológico. El hallazgo de metástasis a distancia en cáncer de ovario tanto en el diagnostico como durante el seguimiento, se encuentra en cerca del 18 por ciento de las pacientes. Las metástasis en piel se han reportado en cifras menores a un 4 por ciento. El compromiso cutáneo se ha descrito como un fenómeno tardío en la historia natural de la, enfermedad, reportándose una sobrevida promedio de 4 meses, posterior al hallazgo de la metástasis en piel. En éste trabajo se reporta el caso de una paciente con éste tipo de diseminación metastásica en piel, junto con una revisión bibliográfica del tema.
Ovarian carcinoma is the second most common gynecologic neoplasm, but it is still the main cause of death among the gynecologic tumors in women. Distant metastases are found in 18 percent of the patients with ovarian carcinoma. Skin metastases of ovarian carcinoma are very rare. It has been reported in almost 4 percent and in some cases as the first manifestation of the disease. Skin metastases have been described as a late manifestation during the natural history of the disease, reporting an average of 4 month survival after the finding of skin lesions. In this paper a case of a patient with this type of metastatic dissemination on skin is reported, including a bibliographic review of the literature.
Subject(s)
Humans , Female , Middle Aged , Adenocarcinoma, Papillary/secondary , Skin Neoplasms/secondary , Ovarian Neoplasms/pathology , Fatal OutcomeSubject(s)
Child , Humans , Adrenal Cortex Hormones/therapeutic use , Dermatitis, Atopic/drug therapy , Hemangioma/drug therapy , Tacrolimus/therapeutic use , Dermatologic Agents/therapeutic use , Immunosuppressive Agents/therapeutic use , Chronic Disease , Hemangioma/classification , Ointments , Tacrolimus/analogs & derivatives , Tacrolimus/pharmacokineticsSubject(s)
Humans , Female , Infant , Anti-Inflammatory Agents, Non-Steroidal , Drug Eruptions , Ibuprofen/adverse effectsABSTRACT
La Adenosín Deaminasa (ADA) es una enzima del catabolismo de las purinas. Puede encontrarse actividad ADA en toda célula, pero alcanza niveles especialmente altos en monocitos y linfocitos T, que son importantes en la inmunidad celular. Nuestro objetivo fue medir la actividad sérica de ADA y la respuesta de hipersensibilidad a tuberculina (PPD) en pacientes con eritema indurado de Bazin (EIB). Se seleccionaron en forma prospectiva 15 pacientes con EIB a las que se les midió actividad ADA (según método de Giusti modificado) y reacción de hipersensibilidad cutánea con 2U de tuberculina (PPD) durante la fase activa de la enfermedad. Las mediciones también se realizaron en 18 mujeres control. El promedio de actividad ADA sérica en la serie en estudio fue de 29,5 U/L y en la serie control fue de 15,6 U/L. El promedio de PPD en la serie en estudio fue de 20,7 mm y en la serie control fue de 7,2 mm. Concluimos que las pacientes con EIB tuvieron niveles de ADA séricos significativamente mayores que las del grupo control, (p<0,0002). También tuvieron valores de PPD significativamente más altos que el control (p<0,00001). No se observó una asociación estadísticamente significativa entre un mayor nivel de ADA y una mayor respuesta cutánea a la tuberculina
Subject(s)
Humans , Female , Adult , Middle Aged , Adenosine Deaminase/metabolism , Erythema Induratum/enzymology , Adenosine Deaminase/blood , Leg Dermatoses/enzymology , Prospective Studies , Tuberculin TestABSTRACT
We report a 29 years old female presenting with fever and painful infiltrated erythematous and violaceous plates with pseudo vesicles in the surface, located in both arms, four days after having suffered a tonsillitis. She was admitted with the diagnosis of Sweet syndrome and the lesions disappeared spontaneously. Two months later, she presented with a similar condition, again after an upper respiratory infection. Five months later, she was admitted with arthralgias with positive rheumatoid factor and antinuclear antibodies. Three years after the first admission, she was admitted with an acute glomerulonephritis and renal failure after another upper respiratory infection. Sweet syndrome was described in 1964 and, although initially considered benign, its association with inflammatory diseases or cancer has been reported